What action should be taken for a suppository prior to usage?

For a suppository to be used effectively, it is crucial to unwrap it before insertion. Suppositories are typically made from materials that help facilitate their melting or dissolving once they are introduced into the body, often containing medications intended to act locally or be absorbed systemically through the rectal mucosa.

Unwrapping the suppository is essential because the packaging is not designed to be ingested and could hinder the medication's release and absorption. Additionally, if the suppository is inserted into the body while still wrapped, it could lead to improper administration and ineffective therapy. Thus, unwrapping ensures that the medication is appropriately positioned for optimal action.

The other options do not reflect correct practices for the use of suppositories. For example, inserting a suppository directly without unwrapping would prevent the medication from being correctly utilized, while chewing it or mixing it with food would negate its proper formulation and purpose.